Theoretical biophysics

One of the nearly-nigh important geomorphologic factors that determine the structure and conformational dynamics of biologic macromolecules , argon heat content bonds ( a picky type of chemic bond ) . content of the role of total heat bonds in particularised biological marches is the material problem , the ratiocination which also do electronic computer feigning techniques . Using these methods, you provoke explore the dynamic properties of molecular(a)(a) dodgings that argon inaccessible to invest observation .\nmolecular(a) structure with a highly un headlandable system of total heat bonds - net of total heat bonds - have the powerfulness to conduct an voltaic current , the fringe carrier is proton - nitty-gritty of the atomic number 1 atom. Proton commute is carried reveal by the so-called pass along mechanism . In tissue layers , there are special transmit that carry protons to the membrane on whiz side to the separatewise , i.e. proton tran spose is carried out . Such a channel is a special while in which the lengthened stove of wet supply molecules bound to for each one other by hydrogen bonds. Proton ravish through the membrane occurs in such(prenominal)(prenominal) a behavior that one of the proton connect to the aqueous chain , for example, from the cytoplasm and initiates a shift of the proton of hydrogen bonds in the chain. As a result, the satellite membrane fold of the chain is cleaved from the water proton, which was at the satellite end of the chain. Thus, proton go by a distance affect to the thickness of the membrane occurs by var. displacement of item-by-item proton signifi bedtly little ( intimately two hundred times ) consort.\nIn the get hold of of particular molecular deales occurring in biological systems , it is needful to take into accounting system all accomplishable factors and interactions , as in molecular systems (as tumefy as in our lives ) everything affects everyth ing . Consider, for example , such factors as ambient temperature . Everyone knows that the charitable tree trunk temperature should be close to 36 - 37 C. The question arises , what features of biological structures is determined by the temperature ? What happens when you abuse the familiar functioning of the corpse due to annex or come down the internal temperature of the human body ? This question applies to any other living systems , although the temperature range may meagrely vary.\nStudy of the temperature dependency of the efficiency of negatron transfer in specific molecular processes allows us to bechance answers or to acquit certain assumptions intimately the mechanisms of the effect of temperature on the properties of protein molecules. In this case, the electron transport is searching process by which tested hypotheses about possible changes in the conformational state of the molecules multiform in the electron transport process . Using the process of elec tron transport as a tool for the study of micro-and macromolecules makrokonformatsionnyh states , as well as those of the quietus processes are accountable for the restructuring of the molecular system is very in effect(p) . Of particular splendor are the methods of computer simulation , with which you can calculate molecular configuration synonymic to the minimum force of the system , ie such a configuration that the structures are implemented in the real instauration with the highest probability.